The 29-year-old Dutch wing-back has been nursing a minor ankle issue that forced him to withdraw early from Netherlands international duty during the November break.
Dumfries sustained the knock in training with the Oranje ahead of their 2026 World Cup qualifiers, prompting coach Ronald Koeman and Inter's medical staff to take a precautionary approach by sending him back to Appiano Gentile for treatment.
Reports from Sky Sport Italia and La Gazzetta dello Sport indicate the problem is mild, with the club confident the defender will be ready for the derby. Dumfries has already begun physiotherapy and is expected to undergo final tests in the coming days.
Inter recalled him from the national team setup to avoid any risk of aggravation, a decision Koeman described as sensible given the congested fixture schedule.
The former PSV man has been a cornerstone of Cristian Chivu's side this season, providing explosive energy and defensive solidity on the right flank.
Recent arrival Luis Henrique has struggled to fully adapt to Serie A demands, making Dumfries' presence even more vital as Inter look to maintain their strong position near the top of the table following recent wins, including a 2-0 victory over Lazio just before the break.
Chivu, who took over from Simone Inzaghi, has frequently highlighted Dumfries' importance to the team's balance and intensity. His potential return would be a significant boost for the Nerazzurri in what is shaping up to be another electrifying edition of the Milan derby.
With both sides locked in a fierce battle for supremacy in Serie A, Dumfries' fitness remains a major talking point as the countdown to one of Italian football's most iconic fixtures intensifies.
